Adrian G. Palacios

 Neurociencia de Circuitos y Sistemas

  • Universidad de Valparaiso, Professor, 1996-
  • Principal Investigator, CINV-UV, 1999-
  • Principal Investigator, Instituto de Sistemas Complejos de Valparaiso, Valparaiso. 2005-
  • Visitant Professor   CORTEX INRIA-UHP et Nancy 2 and CREA Ecole Polytechnique, France. 2008-2010
  • Postdoctoral Fellow and Research Assistant, Yale University. 1991-1997.
  • Dr in Neuroscience, Université de Pierre et Marie Paris VI, France. 1991

 Selected Publications  (2011-):

  1. Vasquez JC, Palacios AG, Marre O, Berry II MJ, Cessac B. (2012). Gibbs distribution analysis of temporal correlation structure on multicell spike trains from retina ganglion cells. Journal of Physiology Paris. 106(3-4):120-7.
  2. Huang S, Treviño M, He K, Ardiles A, Di Pasquale R, Guo Y, Palacios AG, Huganir R and Kirkwood A. (2012) Pull-Push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510.
  3. Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC , Palacios AG. (2012) Post-synaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease. Proceeding National Academy of Science. 109 (34) 13835-13840. Featured in: Pour la Science, Alzheimer Research Forum,   Science Biologiques,
  4. Ardiles A, Ewer J, Acosta ML, Kirkwood A, Martinez A, Ebensperger  LA, Bozinovic  F,  Lee TM, Palacios AG. (2013). Octodon degus (Molina 1782): A model in comparative biology and biomedicine. Cold Spring Harbor Protocols. 4: 312-318.
  5. Palacios AG, Lee TM. (2013). Husbandry and Breeding in the Octodon degus (Molina 1782). Cold Spring Harbor Protocols. 4:350-353.
  6. Ocampo-GarcésA, Hernandez  F, Palacios AG. (2013). REM sleep phase preference in the crepuscular Octodon degus assessed by selective REM sleep deprivationSleep. 36(8):1247-1256.
  7. Vega-Zuniga T, Medina FS, Fredes F, Zuniga C, Severín D, Palacios AG, Karten HJ, Mpodozis J. (2013). Does nocturnality drive binocular vision? Octodontine rodents as a case study. PlosOne New See Citation Metrics
  8. Escobar M.J., Palacios A.G. (2013). Beyond the retina neural coding: On Models and Neural Rehabilitation. J Physiol Paris. 107(5):335-7.
  9. Lowe J, Chang YL, Ardiles AO, Lim JC, Grey AC, Robertson KM, Danesh-Meyer HV,  Palacios AG, Acosta ML. (2014).  Alzheimer’s disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimer & Dementia. 10(2):251–261.
  10. Alvaro O Ardiles, Carolina Flores-Muñoz, Gabriela Toro-Ayala, Ana María Cárdenas, Adrian G Palacios, Pablo Muñoz, Marco Fuenzalida, Juan C Saez, Agustin D Martinez. (2014). Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice. Front. Cell. Neurosci. | doi: 10.3389/fncel.2014.00171
  11. Palacios-Munoz A, Escobar MJ, Vielma A, Araya J, Astudillo A, Garcia I, Valdivia G, Hurtado J, Schmachtenberg O, Martinez AD, Palacios AG (2014) Role of Connexin Channels in the Retinal Light Response of a Diurnal Rodent. Front Cell Neurosci. 2014; 8: 249.
  12. Inestrosa, N. C., Ríos, J. A., Cisternas, P., Tapia-Rojas, C., Rivera, D.S., Braidy, N., Zolezzi, J. M., Godoy, J. A., Carvajal, F. J., Ardiles, A. O., Bozinovic, F., Palacios, A. G. and Sachdev, P. S. (2015), Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer’s Disease. Brain Pathology. doi:10.1111/bpa.12226
  13. Alex H Vielma; Adolfo Agurto; Joaquín Valdés; Adrián G Palacios; Oliver Schmachtenberg. (2014). Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS One, 9(12):e114330
  14. Claudio Elgueta, Alex Harry Vielma, Adrian G Palacios and Oliver Schmachtenberg. (2015). Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Frontiers in Cellular Neuroscience 9(6):1-11.
  15. Lucia Y Du, Lily Y-L Chang, Alvaro O Ardiles, Cheril Tapia-Rojas, Joaquin Araya, Nibaldo C Inestrosa, Adrian G Palacios* and Monica L Acosta*. (2015). Alzheimer’s disease-related protein expression in the retina of aged Octodon degus. Plos One. DOI: 10.1371/journal.pone.0135499. *equal contribution.
  16. Hui Wang, Alvaro Ardiles, Sunggu Yang, Gonzalo Valdivia, Min Baek, Trinh Tran, Rafael Posada-Duque, Yang-An Chuang, Adrian G. Palacios, Michela Gallagher, Paul Worley, Alfredo Kirkwood. (2016). Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the hippocampus. The Journal of Neuroscience, 3 February 2016, 36(5):1723-1729; doi:10.1523/JNEUROSCI.0878-15.2016.
  17. Claudia Salazar, Gonzalo Valdivia, Álvaro O Ardiles, John Ewer, Adrián G Palacios. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural models. Biol Res (2016) 49:14 DOI 10.1186/s40659-016-0072-9.
  18. Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BK, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. (2016). Regulation of memory formation y the transcription factor XBP1 Cell Reports: 14(6):138-1394. 1016/j.celrep.2016.01.028
  19. Vega-Zuniga T, Medina FS, Karten HJ, Marín G, Letelier JC, Palacios AG, Nemec P, Schleich CE, Mpodozis J. (2017). Selective binocular vision loss in two subterranean caviomorph rodents: Spalacopus cyanus and Ctenomys talarum. Scientific Reports | 7:41704 | DOI: 10.1038/srep41704. 1-12.
  20. Claudia Duran-Aniotz, Victor Hugo Cornejo, Sandra Espinoza, Álvaro O. Ardiles, Danilo B. Medina, Claudia Salazar, Andrew Foley, Ivana Gajardo, Peter Thielen, Takao Iwawaki, Wiep Scheper, Claudio Soto, Adrian G. Palacios, Jeroen J. M. Hoozemans, Claudio Hetz. (2017) IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. “IRE1 signaling exacerbates Alzheimer’s disease pathogenesis”. Acta Neuropathol doi:10.1007/s00401-017-1694-x
  21. Palacios A.G, Escobar M.J., Céspedes E. (2017). Missing colors: an enactivist approach to perception. Constructivist Foundations, Volume 13, Number 1, pp 117-125 (link).
  22. Palacios A.G, Escobar M.J., Céspedes E. (2017). Authors’ Response: Is a Weak Notion of Representation not Compatible with a Contextualist and Enactivist Account of Perception?. Constructivist Foundations, Volume 13, Number 1, pp 135-140 (link).
  23. Rubén Herzog, Maria-Jose Escobar, Rodrigo Cofre, Adrian G. Palacios, Bruno Cessac. 2018. Dimensionality Reduction on Spatio-Temporal Maximum Entropy Models of Spiking Networks. BioRxiv doi:
  24. Elgueta C, Leroy F, Schmachtenberg O, Palacios AG. 2018. Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells”. Scientific Reports 8, 3123. doi:10.1038/s41598-018-21119-0
  25. Maria-Jose Escobar, Monica Otero, Cesar Reyes, Ruben Herzog, Joaquin Araya, Cristobal Ibaceta, Adrian G. Palacios. 2018. Functional Asymmetries between Central and Peripheral Retinal Ganglion Cells in a Diurnal Rodent. BioRxiv 277814; doi:

Actual Collaborations

  1. Computational Neuroscience: INRIA (Frederique AlexandreThierry VievilleBruno Cessac, France), Maria Jose Escobar , USM, Chile.
  2. Neurodegeneration (Alfredo Kirkwood , Hopkins U, USA, Chile, Monica Acosta, U Auckland; Claudio Hetz, UCH, Chile)

Postdoctoral & Research Fellows (2016-)

  1. 2018- Paloma Harcha, Neuroinflamation, Retina / Hipocampus, Posdoctoral Fellow.
  2. 2017-2021. Nicolas Palanca, Spain, Melanopsins. Posdoctoral Fellow CINV and FONDECYT.
  3. 2017- Ruben Herzog, Research Fellow.

Graduate Students (2013-)

  1. 2017- Joaquin Araya, PhD in Neuroscience, USACH.
  2. 2017- Cristobal Ibaceta, PhD in Science mention Neuroscience.
  3. 2017-2018 Soraya Mora, Master in Science mention Neuroscience UV
  4. 2014-2016 Ruben Herzog, Master of Science, Universidad de Chile. Tutor
  5. 2014-2016 Camilo Miguel, Master in Science mention Neuroscience UV
  6. 2013-2016 Claudia Salazar, Master in Science mention Neuroscience UV
  7. 2013-2018 Cesar Ravello, PhD in Science mention Neuroscience. UV. Tutor

Research Assistant/ Undergraduated / Internships (2013-)

  1. 2018 Vanessa Munoz, Biochemistry
  2. 2016. Cristobal Ibaceta, Biochemistry
  3. 2016- David Neira, Biochemistry
  4. 2015-2016. Felipe Olivares, Biochemistry
  5. 2015 Arnaud Ruggeri-Begeault,  France, Lyon INSA
  6. 2014-2015 Ivana Gajardo, Biochemistry
  7. 2013-2015 Gonzalo Valdivia, Biochemistry
  8. 2013- 2015 Michael Pizarro, Biology

Past Postdoc / Past PhD / Master: Actual Position

  1. Dr. Adrian Ocampo, Associate Profesor, Universidad de Chile.
  2. Dr. Juan Cristobal Zagal, Associate Profesor, Universidad de Chile
  3. Dr. Alvaro Ardiles, Assistant Professor,  Universidad de Valparaiso
  4. Dr. Tatiana Cevo, Ophthalmology, Assistant Professor, Universidad de Valparaiso
  5. Dr.Pablo Munoz, Assistant Professor,  Universidad de Valparaiso
  6. Dr. Andres Chavez, Assistant Professor, Universidad de Valparaiso
  7. Dr. Claudio Elgueta, Academic Staff, University of Freiburg
  8. Dr. Jose Hurtado, Industry.


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